|
![]() |
貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
JD1227177491 | 4-1BBL (TNFSF9) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
性狀: | 【反應特異性】Human 【克隆 ID】EPR1172Y 【用途】WB , IHC , ICC , IP 【抗原分子量】26kDa |
質(zhì)量標準: | 【產(chǎn)品介紹】4-1BB was originally described as a cDNA expressed by activated murine T cells and subsequently demonstrated to encode a member of the tumor necrosis factor receptor family of integral membrane proteins. Recently, a murine ligand for 4-1BB (mu4-1BB-L) was cloned and demonstrated to be a member of an emerging family of ligands with structural homology to tumor necrosis factor. Both monoclonal antibody to hu4-1BB and cells transfected with hu4-1BB-L induced a strong proliferative response in mitogen co-stimulated primary T cells. In contrast, ligation of 4-1BB on T cell clones enhanced activation-induced cell death when triggered by engagement of the TCR/CD3 complex. (1). To reject tumors, T cells must overcome poor tumor immunogenicity and an adverse tumor microenvironment. It has been shown that primary human T cells expressing CD80 and 4-1BBL vigorously respond to tumor cells lacking costimulatory ligands and provoke potent rejection of large, systemic tumors in immunodeficient mice (2).
WB, IHC, ICC, IP WB: 1:500 Human *Cross reactivity determined by western blot only. Specificity A synthetic peptide corresponding to residues near |
貯存: | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), |