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貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
JD1227177487 | 14-3-3 sigma (SFN) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
性狀: | 【反應(yīng)特異性】Human , Mouse , Rat 【克隆 ID】EPR5872 【用途】WB 【抗原分子量】28kDa |
質(zhì)量標準: | 【產(chǎn)品介紹】14-3-3 proteins are composed of a highly conserved multigene family of small acidic proteins. Responsive to DNA damage, 14-3-3 sigma expression is induced in a p53-dependent manner. 14-3-3 sigma sequesters cyclin B1-CDC2 complex in cytoplasm, and prevents its entry into nucleus resulting in G2/M cell cycle arrest. Furthermore, 14-3-3 sigma can link to CDK2 and CDK4 and block the cell cycle entry. Thus, 14-3-3 sigma acts as a negative regulator of cell cycle progression and is linked to cancer (1). A keratinocyte-releasable form of 14-3-3 sigma is a potent MMP-1-stimulatory factor in dermal fibroblasts. When it is released from keratinocytes, it induces the expression of MMP1, MMP3, MMP8 and MMP24 in fibroblasts through the p38 mitogen-activated protein kinase (MAPK) signaling pathway (2). Recommended Applications WB WB: 1:1,000 - 10,000 Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Western blot analysis on (A) fetal lung, (B) A549, Specificity A synthetic peptide corresponding to residues in |
貯存: | Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, |